About Us
Innovation in Motion
NanoMedTrix is a biotechnology company that develops and manufactures innovative nanoparticles for use in a variety of medical applications. Our nanoparticles are uniquely visible in echo, MRI, CT and by fluorescence, making them ideal for use in studies of carriers for therapeutic payload to a site of interest.
In addition to our core business of nanoparticle development and manufacturing, we also offer a variety of services to the scientific community, including patent-pending multi-scale tools for research into early detection and treatment of diseases.
Our Mission
Our mission is to develop and deliver innovative nanoparticles that improve the lives of patients around the world. We are committed to providing the highest quality products and services, and to working with our partners to advance the field of nanotechnology.
Our Story
Who We Are
NanoMedtrix, LLC (NMTx) was created in 2012 as a spin-off of research by Dr. Assouline at the University of Iowa and NIH, NINDS.
The end goal is to produce clinical-stage oncology/and curative enterprise designed to advance the development of a nanoscale particle platform technology. Through surface modifications, targeted particles will impart specificity of the loaded cargo to tumor and cancer cells. Thus, this material inherently spares non-cancerous, normal tissue from toxicity seen with traditional, systemic treatments. Recent breakthroughs in advanced interventional cancer treatment (and other major diseases) have enabled and warrant the development of targeted options with theragnostic impact.
Our Breakthroughs
Technological Impact
Recent breakthroughs and advances in interventional cancer treatment and other major diseases have enabled and warrant the development of targeted options with theragnostic impact.
At NanoMedTrix, multi-pronged efforts are underway to increase manufacturing capacity and improve potential toxicity inherent to systemic therapeutic delivery. Our materials uniquely feature options to bolster consistent monitoring using radiographic imaging in conjunction with chemotherapeutic treatment. Pre-clinical trials are underway to evaluate the efficiency of nano-based drug delivery with augmented specificity. Several models are being assessed for escalating doses and improved selectivity of chemotherapies while encouraging immunomodulation and paving the way for clinical trials.
Our Technology
NanoMedtrix has reached scaling-up levels for commercial applications, including manufacturing strategies for purities, excluding toxic materials, and ready-to-GMP preparations. The loading capacity can be adjusted to accommodate the molecular size of the cargo and the most suitable dosage requirement. In addition, the synthesis incorporates co-crystallization with agents known to have contrast signals in MRI, CT, and Ultrasound. This unique feature allows for real-time/non-invasive monitoring of therapeutic success. Imaging and particle-mediated treatment have been optimized in wide orthotopic and xenograft models. Targeting as surface modification provides yet another level of specificity to the drugs delivered. Our products have been tested for tumoricidal effects with various drug classes such as taxanes, antineoplastic antibiotics, antimetabolite agents, and anti-angiogenic. Multi-drug treatment and sequential regiment cycles and treatment modalities (oral, intravesicular, per-rectum, intravascular) have been consistently given high levels of cancer reduction while showing a fast clearance.
Looking Forward
Our Future
As interventional technology advances through enhanced imaging and AI-enabled refinements, so does the therapeutic options.
NanoMedtrix has, from the start, answered the demand and focused on combining powerful tools to simultaneously monitor and selectively treat a wide range of diseases with
effective drugs and new untrialed drugs. Bladder cancer has been used as model of local disease with a
clear need for targeted and rapid treatment to prevent progression into metastatic foci. Remarkably, the nanoscale size allows for deeper penetration of the particle-drug to reach deeper muscle layers,
providing an unprecedented option for advanced tumors. Through this approach, there also exist the
potential to elicit immunodulation locally/systemic and while minimizing systemic unwanted reactions.
Our Team Members
Our team of scientists and engineers is dedicated to developing innovative nanoparticles that improve the lives of patients around the world. We are committed to providing the highest quality products and services, and to working with our partners to advance the field of nanotechnology.
We have been the recipient of several NSF and NIH SBIR awards as well as state and pitch competition winners. Recently, we developed partnerships with the clinical and commercial sectors. We developed models for bladder cancer in two pre-clinical models (mice and dogs) and are poised to begin investigations and sample preparation (scale up and pharmaceutic preps) for first in human.
Dr. Assouline has held academic positions in Medicine and Engineering at the University of Iowa. His research focuses on developing novel target molecules and bioactive markets. He began his quest for a reliable market technology that could serve simultaneously as a diagnostic tool and therapeutic alternative while at the National Institutes of Health. This led to a number of innovative designs, which culminated in the development of a series of nano-scale multifunctional particles with applications in biotechnology and medicine.
Dr. Sweeney has extensive training and hands-on experience in all research interests of NanoMedTrix. He has applied his knowledge of nanomaterials in a variety of biomedical applications and led teams of scientists in the development and experimental designs of labeling and imaging contrast enhancement.
Innovate with Us
Careers
NanoMedTrix is actively looking to hire a postdoc or scientist-level researcher. The researcher will participate in planning, designing, and conducting highly technical operations in teamwork with other scientists and the Principal Investigator. Will analyze research data, provide interpretations, contribute to developing research documentation for publications, and provide technical reports, papers, and records.
Internships
Join NanoMedTrix and pursue your passion for discovery! We welcome young investigators who are curious and eager to explore new and existing discoveries in biotechnology. Our team offers a unique opportunity for candidates to try themselves at commercialization. Don’t hesitate to inquire about how to apply! Contact Dr. Joe Assouline at 319-335-4676 to learn more about joining the NanoMedTrix team.
Invest in the Future
Nanomedicine is a vigorous and expanding branch of medicine. It has unlimited boundaries at the forefront of biomedical advancement in therapeutics. It bridges the gap between the state of the art in chemistry, physics, medical imaging, and medical treatment of emergent diseases.
NanoMedTrix, has thrived in the development of modern materials and consistently improving and expanding the scope of its reach. Partners in the various sectors of science have already been pivotal in our success, and we are seeking to enroll new ventures and dynamic/disrupting new
directions.
Please join us and let us know how we can work together in this adventure….
Get in Touch
If you would like to learn more about Nanomedtrix and our innovative nanotechnology-based solutions, please contact us today. We would be happy to answer any questions you may have and help you find the right product for your needs.
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